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A Smart Theranostic Platform for Photoacoustic and Magnetic Resonance Dual-imaging-guided Photothermal-Enhanced Chemodynamic therapy

Abstract

The use of smart theranostic agents in multimodal imaging and treatment is a promising strategy to overcome the limitations of single mode diagnosis and treatment, and can greatly improve the diagnosis and effects of treatment. In this study, a gold@manganese dioxide (Au@MnO2) core-shell nanostructure was designed as a glutathione (GSH)-triggered smart theranostic agent for photoacoustic and magnetic resonance (MR) dual-imaging-guided photothermal-enhanced chemodynamic therapy. Both in vitro and in vivo experiment demonstrated not only that the photoacoustic and MR imaging function of Au@MnO2 could be activated by an endogenous high GSH concentration, but also that after being triggered by the endogenous GSH, Au@MnO2 had an excellent synergistic treatment effect in photothermal-enhanced chemodynamic therapy under the guidance of photoacoustic and MR imaging. This study demonstrated that the use of GSH-triggered Au@MnO2 in photoacoustic and MR dual-imaging-guided photothermal-enhanced chemodynamic therapy is a smart theranostic nanoplatform for the accurate diagnosis and efficient treatment of cancer.

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Supplementary files

Article information


Submitted
26 Nov 2019
Accepted
30 Jan 2020
First published
06 Feb 2020

Nanoscale, 2020, Accepted Manuscript
Article type
Paper

A Smart Theranostic Platform for Photoacoustic and Magnetic Resonance Dual-imaging-guided Photothermal-Enhanced Chemodynamic therapy

H. Wang, L. An, C. Tao, Z. Ling, J. Lin, Q. Tian and S. Yang, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/C9NR10039C

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