Jump to main content
Jump to site search


Synthesis of Gadolinium/Iron-Bimetal-Phenolic Coordination Polymer Nanoparticles for Theranostic Applications

Abstract

Integration of diagnostic and therapeutic components into a single coordination polymer nanoparticle is desirable for theranostic applications, but still challenging. Herein, we report the synthesis of bimetal-phenolic coordination polymer nanoparticles using gadolinium nitrate and ferrous sulphate as a metal source, plant polyphenol (i.e., tannic acid) as an organic ligand via a metal-catechol coordination assembly process. Such coordination polymers show tunable molar ratio of Gd/Fe, high dispersibility and stability in aqueous solution. The coordination polymers reveal composition-dependent performance for longitudinal relaxivity and photothermal conversion. The longitudinal relaxivity is positively related to the molar ratio of Gd/Fe, while the photothermal performance is negatively related to the molar ratio of Gd/Fe in the coordination polymers. The coordination polymers with optimized molar ratio of Gd/Fe exhibit ultra-small hydrodynamic diameter (~23 nm), high r1 value (9.3 mM-1 s-1) with low r2/r1 (1.26) and high photothermal conversion efficiency (η=37%). They can be used as a contrast agent for T1-weighted magnetic resonance imaging of EMT-6 tumor bearing mice, which can effectively enhance the signals of tumor. They can also effectively suppress tumor growth via photothermal therapy. This work brings new insights for the synthesis of multifunctional coordination polymer nanoparticles and extend their potential applications in theranostic.

Back to tab navigation

Supplementary files

Article information


Submitted
25 Nov 2019
Accepted
09 Feb 2020
First published
13 Feb 2020

Nanoscale, 2020, Accepted Manuscript
Article type
Paper

Synthesis of Gadolinium/Iron-Bimetal-Phenolic Coordination Polymer Nanoparticles for Theranostic Applications

J. Qin, G. Liang, Y. Feng, B. Feng, G. Wang, N. Wu, Y. Zhao and J. Wei, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/C9NR10020B

Social activity

Search articles by author

Spotlight

Advertisements