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Core-Shell Structured 5-FU@ZIF-90@ZnO as a Biodegradable Nanoplatform for Synergistic Cancer Therapy

Abstract

High treatment efficiency and low toxicity of drugs are two key factors in tumor therapy. The development of multifunctional drug carrier systems is of great significance for the diagnosis and therapy of tumor. Herein, the new biodegradable treatment system based on zeolitic imidazolate framework-90 (ZIF-90) was designed in this study. This 5-FU@ZIF-90@ZnO (FZZ) drug delivery system achieves synergistic treatment of antineoplastic 5-fluorouracil (5-FU) and zinc oxide, and also has good dispersibility in the acidic tumor microenvironment (TME), which enables the drug to achieve pH-controlled delivery in acidic organisms. Interestingly, zinc oxide nanoparticles can play a dual role here. It has access to restraint premature leakage of drugs in a physiological condition. Moreover, Zn2+ produced after the decomposition of nanoparticles can act as a therapeutic agent, overcoming the tumor resistance to 5-FU and regulating a series of physiological reactions to inhibit tumor growth. It is worth noting that the porous ZIF-90 is an emerging drug carrier with a relatively high drug loading rate of 39% in this study. Synergistic 5-FU and ZnO nano-particles have achieved tumor inhibition and shown the high therapeutic biosafety. Thus, the FZZ core-shell nanoparticle is a potential pH-controlled drug release system that can be applied to tumor treatment.

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Supplementary files

Article information


Submitted
20 Nov 2019
Accepted
14 Jan 2020
First published
15 Jan 2020

Nanoscale, 2020, Accepted Manuscript
Article type
Paper

Core-Shell Structured 5-FU@ZIF-90@ZnO as a Biodegradable Nanoplatform for Synergistic Cancer Therapy

X. Xiao, S. Liang, Y. Zhao, D. Huang, B. Xing, Z. Cheng and J. Lin, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/C9NR09869K

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