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Issue 3, 2020
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A glutathione-depleting chemodynamic therapy agent with photothermal and photoacoustic properties for tumor theranostics

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Abstract

Nowadays, Fenton reaction-based chemodynamic therapy (CDT) strategies have drawn extensive attention as tumor-specific nanomedicine-based therapy. Nevertheless, current existing CDTs normally suffer from therapeutic bottlenecks such as the scavenging of hydroxyl radical (˙OH) by intracellular antioxidants and unideal therapeutic outcome of single treatment modality. Herein, we constructed novel all-in-one AFP nanoparticles (NPs) as CDT agents through a one-pot process for multifunctional nanotheranostics. The as-constructed AFP NPs could simultaneously produce ˙OH through the Fenton reaction and scavenge intracellular glutathione, functioning as self-reinforced CDT agents to achieve tumor-triggered enhanced CDT (ECDT). In addition, the AFP NPs possessed the capability of H2O2 and acid-boosted photoacoustic imaging and photothermal therapy, enabling a precise and effective tumor therapeutic outcome with minimal nonspecific damage in combination with ECDT. Our novel nanoplatform would open new perspectives on multi-functional CDT agents for accurate and non-invasive tumor theranostics.

Graphical abstract: A glutathione-depleting chemodynamic therapy agent with photothermal and photoacoustic properties for tumor theranostics

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Article information


Submitted
19 Nov 2019
Accepted
17 Dec 2019
First published
17 Dec 2019

Nanoscale, 2020,12, 1349-1355
Article type
Communication

A glutathione-depleting chemodynamic therapy agent with photothermal and photoacoustic properties for tumor theranostics

F. Liu, L. Lin, S. Sheng, C. Xu, Y. Wang, Y. Zhang, D. Wang, J. Wu, Y. Li, H. Tian and X. Chen, Nanoscale, 2020, 12, 1349
DOI: 10.1039/C9NR09858E

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