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Co-assembly of HPV Capsid Proteins and Aggregation-induced Emission Fluorogens for Improved Cell Imaging

Abstract

Fluorescence imaging is one of the important techniques for non-invasive bio-sensing and -tracking. In this work, the fluorescent nanoparticles were prepared by co-assembly of human papillomavirus (HPV) capsid protein and a complex composed of DNA and aggregation-induced emission fluorogen (AIEgen) 9,10-distyrylhydrazine (DSAI), where the virus-like particles (VLPs) encapsulate the complex via electrostatic interaction. The co-assembled nanoparticles, DSAI-DNA@VLPs, showed homogeneous size, improved fluorescence, considerable stability, good biocompatibility and commendable protection for the DSAI-DNA complex, ensuring their good ability for imaging in live cells.

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Supplementary files

Article information


Submitted
24 Oct 2019
Accepted
04 Feb 2020
First published
05 Feb 2020

Nanoscale, 2020, Accepted Manuscript
Article type
Paper

Co-assembly of HPV Capsid Proteins and Aggregation-induced Emission Fluorogens for Improved Cell Imaging

J. Jing, Y. Xue, Y. Liu, B. Xu, H. Li, L. Liu, Y. Wu and W. Tian, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/C9NR09084C

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