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Mitochondrion-targeted selenium nanoparticles enhance reactive oxygen species-mediated cell death

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Abstract

Selenium nanoparticles (SeNPs) can induce reactive oxygen species (ROS)-mediated cell death when accumulated in cancer cells, while rendering anti-oxidation and cancer prevention in healthy tissues at low doses. Although they are promising anticancer agents with fewer side effects, their application is limited by their relative low toxicity to cancer cells. Therefore, we propose a mitochondrion-targeting strategy to improve their cancer cell killing efficiency. Such mitochondrion-targeted SeNPs could efficiently increase ROS production and mitochondrion damage in cancer cells; however, only a slightly increased toxicity to normal cells was observed, indicating a potentially better therapeutic window for anticancer treatments.

Graphical abstract: Mitochondrion-targeted selenium nanoparticles enhance reactive oxygen species-mediated cell death

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Article information


Submitted
22 Oct 2019
Accepted
19 Dec 2019
First published
20 Dec 2019

Nanoscale, 2020, Advance Article
Article type
Communication

Mitochondrion-targeted selenium nanoparticles enhance reactive oxygen species-mediated cell death

Y. Zhuang, L. Li, L. Feng, S. Wang, H. Su, H. Liu, H. Liu and Y. Wu, Nanoscale, 2020, Advance Article , DOI: 10.1039/C9NR09039H

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