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A strong CD8+ T cell-stimulating supramolecular hydrogel

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The development of molecules with immune stimulatory properties is crucial for cancer immunotherapy. In this work, we combined two peptide-based molecules, tuftsin (TKPR) and Nap-GDFDFDY, to develop a novel self-assembling molecule Nap-GDFDFDYTKPR (Comp. 3), which has strong CD8+ T cell stimulatory properties. Comp. 3 could self-assemble into nanofibers and hydrogels, which significantly improved the stability of tuftsin against enzyme digestion. The nanofibers of Comp. 3 enhanced the phagocytic activity of macrophages, promoted the maturation of DCs, and stimulated the expression of cytokines. In addition, it demonstrated an excellent anti-tumor efficacy in vivo by eliciting a strong CD8+ T immune response. Taken together, our observations revealed a powerful immune stimulating nanomaterial that is a promising compound for cancer immunotherapy.

Graphical abstract: A strong CD8+ T cell-stimulating supramolecular hydrogel

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Article information

18 Oct 2019
23 Dec 2019
First published
27 Dec 2019

Nanoscale, 2020, Advance Article
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A strong CD8+ T cell-stimulating supramolecular hydrogel

X. Li, Y. Wang, S. Wang, C. Liang, G. Pu, Y. Chen, L. Wang, H. Xu, Y. Shi and Z. Yang, Nanoscale, 2020, Advance Article , DOI: 10.1039/C9NR08916K

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