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Issue 3, 2020
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Exploiting the protein corona: coating of black phosphorus nanosheets enables macrophage polarization via calcium influx

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Abstract

Black phosphorus nanosheets (BPNSs) have substantially promoted biomedical nanotechnology due to their unique photothermal and chemotherapeutic properties. However, there is still a limited molecular understanding of the effects of bio-nano interfaces on BPNSs and the subsequent impacts on physiological systems. Here, it is shown that black phosphorus–corona complexes (BPCCs) could function as immune modulators to promote the polarization of macrophages. Mechanistically, BPCCs could interact with calmodulin to activate stromal interaction molecule 2 and facilitate Ca2+ influx in macrophages, which induced the activation of p38 and NF-κB and polarized M0 macrophages to the M1 phenotype. As a result, BPCC-activated macrophages show greater migration towards cancer cells, 1.3–1.9 times higher cellular cytotoxicity and effective phagocytosis of cancer cells. These findings offer insights into the development of potential and unique applications of corona on BPNSs in nanomedicine.

Graphical abstract: Exploiting the protein corona: coating of black phosphorus nanosheets enables macrophage polarization via calcium influx

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Supplementary files

Article information


Submitted
06 Oct 2019
Accepted
02 Dec 2019
First published
02 Dec 2019

Nanoscale, 2020,12, 1742-1748
Article type
Paper

Exploiting the protein corona: coating of black phosphorus nanosheets enables macrophage polarization via calcium influx

J. Mo, Y. Xu, X. Wang, W. Wei and J. Zhao, Nanoscale, 2020, 12, 1742
DOI: 10.1039/C9NR08570J

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