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Anisotropic protein diffusion on nanosurface

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Abstract

The unique puckered structure of α-phase phosphorene carbide (α-PC) results in anisotropic electronic and thermal transporting properties. In the present work, the interactions between a model protein, villin headpiece sub-domain (HP35), and the surface of α-PC and monolayer black phosphorus (MBP, another puckered nanostructure) were explored by molecular dynamic (MD) simulations. It is found that HP35 diffuses quickly only along the zigzag direction of the α-PC surface. On the MBP surface, HP35 migrates mainly along the zigzag direction but can also easily stride over the ridges and grooves along the armchair direction. Moreover, the mild binding strength between α-PC and HP35 does not cause distortion in the protein structure. The intrinsic biocompatibility of α-PC, which is distinct from several other widely studied nanomaterials, such as carbon nanotubes, graphene and MoS2, makes it a promising candidate in functional biomedical applications.

Graphical abstract: Anisotropic protein diffusion on nanosurface

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Article information


Submitted
08 Oct 2019
Accepted
28 Jan 2020
First published
29 Jan 2020

Nanoscale, 2020, Advance Article
Article type
Paper

Anisotropic protein diffusion on nanosurface

Y. Liu, X. Song, Y. Yang, Y. Li, M. Zhao, Y. Mu and W. Li, Nanoscale, 2020, Advance Article , DOI: 10.1039/C9NR08555F

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