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Enhanced eradication of bacterial biofilms with DNase I-loaded silver-doped mesoporous silica nanoparticles

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Abstract

Deoxyribonuclease I (DNase I) was successfully loaded and delivered by silver-doped mesoporous silica nanoparticles (MSN-Ag) for biofilm treatments. This nanoformulation showed enhanced antibacterial effects for both Gram-negative and Gram-positive biofilms by promoting the biofilm biomass dispersing ability of DNase I.

Graphical abstract: Enhanced eradication of bacterial biofilms with DNase I-loaded silver-doped mesoporous silica nanoparticles

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Article information


Submitted
02 Oct 2019
Accepted
16 Nov 2019
First published
19 Nov 2019

Nanoscale, 2020, Advance Article
Article type
Communication

Enhanced eradication of bacterial biofilms with DNase I-loaded silver-doped mesoporous silica nanoparticles

W. Tasia, C. Lei, Y. Cao, Q. Ye, Y. He and C. Xu, Nanoscale, 2020, Advance Article , DOI: 10.1039/C9NR08467C

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