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Au nanoparticles deposited on ultrathin two-dimensional covalent organic framework nanosheets for in vitro and intracellular sensing

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Abstract

A novel composite nanomaterial is prepared by growing small Au nanoparticles on two-dimensional covalent organic framework nanosheets (Au NPs/COF NSs). The synthesized hybrid nanosheets are used as a new platform for multiplexed detection of hepatitis A virus DNA (HAV) and hepatitis B virus DNA (HBV). Additionally, this sensing platform based on Au NPs/COF NSs can be used as a candidate for monitoring the distribution of potassium ions (K+) and the intracellular K+ level in living cells. Accordingly, the sensing systems based on hybrid Au NPs/COF NSs have shown great potential for the investigation of biomolecules and related biological applications.

Graphical abstract: Au nanoparticles deposited on ultrathin two-dimensional covalent organic framework nanosheets for in vitro and intracellular sensing

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Article information


Submitted
24 Sep 2019
Accepted
16 Mar 2020
First published
20 Mar 2020

Nanoscale, 2020, Advance Article
Article type
Paper

Au nanoparticles deposited on ultrathin two-dimensional covalent organic framework nanosheets for in vitro and intracellular sensing

Y. Tian, Q. Lu, X. Guo, S. Wang, Y. Gao and L. Wang, Nanoscale, 2020, Advance Article , DOI: 10.1039/C9NR08220D

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