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Biocompatible iron(III) carboxylate Metal-Organic Frameworks as promising RNA nanocarriers

Abstract

Despite the great interest of RNA therapeutics, a successful gene delivery process is still a major challenge. We propose an efficient nucleic acid entrapping into the mesoporosity of biocompatible nanoscaled metal-organic frameworks. Their rapid cellular uptake together with RNA protection and release led to a relevant in vitro gene activity.

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Article information


Submitted
20 Sep 2019
Accepted
20 Jan 2020
First published
22 Jan 2020

Nanoscale, 2020, Accepted Manuscript
Article type
Communication

Biocompatible iron(III) carboxylate Metal-Organic Frameworks as promising RNA nanocarriers

T. HIDALGO CRESPO, M. Alonso Nocelo, B. Lopez Bouzo, S. Reimondez Troitiño, C. Abuin Redondo, M. de la Fuente Freire and P. Horcajada, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/C9NR08127E

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