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Biocompatible iron(iii) carboxylate metal–organic frameworks as promising RNA nanocarriers

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Abstract

Despite the great interest in RNA therapeutics, the development of a successful gene delivery process is still a major challenge. We propose an efficient nucleic acid entrapment into the mesopores of biocompatible nanoscaled metal–organic frameworks. Their rapid cellular uptake together with RNA protection and release led to a relevant in vitro gene activity.

Graphical abstract: Biocompatible iron(iii) carboxylate metal–organic frameworks as promising RNA nanocarriers

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Submitted
20 Sep 2019
Accepted
20 Jan 2020
First published
22 Jan 2020

Nanoscale, 2020, Advance Article
Article type
Communication

Biocompatible iron(III) carboxylate metal–organic frameworks as promising RNA nanocarriers

T. Hidalgo, M. Alonso-Nocelo, B. L. Bouzo, S. Reimondez-Troitiño, C. Abuin-Redondo, M. de la Fuente and P. Horcajada, Nanoscale, 2020, Advance Article , DOI: 10.1039/C9NR08127E

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