Jump to main content
Jump to site search


A multiple mode integrated biosensor based on higher order Fano metamaterials

Author affiliations

Abstract

A multiple mode integrated biosensor based on higher order Fano metamaterials (FRMMs) is proposed. The frequency shifts (Δf) of x-polarized quadrupolar (Qx), octupolar (Ox), hexadecapolar (Hx), y-polarized quadrupolar (Qy) and octupolar (Oy) Fano resonance modes are integrated to detect the concentration of lung cancer cells. In experiments, the concentrations of lung cancer cells can be distinguished by the shape and distribution of integrated graphics. In addition, an anomalous response in Δf in resonant mode is surprisingly observed. As the cell concentration increases, the Δf at the Qx-dip, Qy-dip and Oy-dip successively experiences an increasing frequency shift stage (IFSS), decreasing frequency shift stage (DFSS) and re-increasing frequency shift stage (RIFSS). The extraordinary DFSS confirmed by single-factor analysis of variance (ANOVA) means an unusual physical phenomenon in metamaterial biosensors. By introducing a new dielectric constant εf, we amend perturbation theory to explain the unusual phenomenon in Δf. With the change of the mode order from Qx to Hx, the εf increases from −2.78 to 0.75, which implies that the negative εf leads to the appearance of the DFSS. As a platform for biosensing, this study opens a new window from the perspective of multiple mode integration.

Graphical abstract: A multiple mode integrated biosensor based on higher order Fano metamaterials

Back to tab navigation

Supplementary files

Article information


Submitted
10 Sep 2019
Accepted
30 Nov 2019
First published
04 Dec 2019

Nanoscale, 2020, Advance Article
Article type
Paper

A multiple mode integrated biosensor based on higher order Fano metamaterials

X. Yan, Z. Zhang, L. Liang, M. Yang, D. Wei, X. Song, H. Zhang, Y. Lu, L. Liu, M. Zhang, T. Wang and J. Yao, Nanoscale, 2020, Advance Article , DOI: 10.1039/C9NR07777D

Social activity

Search articles by author

Spotlight

Advertisements