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Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds

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Abstract

Covering: up to the beginning of 2020

Many natural substances have been transformed again and again with regard to their pharmaceutical-medical potential, including new members of a growing class of natural products, the flavaglines. Important representatives are rocaglamide and silvestrol, isolated from the Aglaia species, which are highlighted here. These products started as potential anti-tumor agents five decades ago and have recently proved to be very promising antiviral agents, especially against RNA viruses. Today they are discussed as potential starting compounds for developing drug candidates and therapeutics.

Graphical abstract: Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds

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Article information


Submitted
14 May 2020
First published
23 Jul 2020

Nat. Prod. Rep., 2020, Advance Article
Article type
Highlight

Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds

G. Schulz, C. Victoria, A. Kirschning and E. Steinmann, Nat. Prod. Rep., 2020, Advance Article , DOI: 10.1039/D0NP00024H

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