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Cytotoxic and antitumor peptides as novel chemotherapeutics

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Abstract

Covering: up to 2020

Treatment resistance and drug-induced refractory malignancies pose significant challenges for current chemotherapy drugs. There have been increasing research efforts aimed at developing novel chemotherapeutics, especially from natural products and related derivatives. Natural cytotoxic peptides, an emerging source of chemotherapeutics, have exhibited the advantage of overcoming drug resistance and displayed broad-spectrum antitumor activities in the clinic. This highlight examines the increasingly popular cytotoxic peptides from isolated natural products. In-depth review of several peptides provides examples for how this novel strategy can lead to the improved anti-tumor effects. The mechanisms and current application of representative natural cytotoxic peptides (NCPs) have also been discussed, with a particular focus on future directions for interdisciplinary research.

Graphical abstract: Cytotoxic and antitumor peptides as novel chemotherapeutics

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Article information


Submitted
22 Apr 2020
First published
10 Aug 2020

Nat. Prod. Rep., 2020, Advance Article
Article type
Highlight

Cytotoxic and antitumor peptides as novel chemotherapeutics

X. Luan, Y. Wu, Y. Shen, H. Zhang, Y. Zhou, H. Chen, D. G. Nagle and W. Zhang, Nat. Prod. Rep., 2020, Advance Article , DOI: 10.1039/D0NP00019A

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