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Biologically active marine natural products and their molecular targets discovered using a chemical genetics approach

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Abstract

Covering: 2000 to 2019

The discovery of new natural products that have some combination of unprecedented chemical structures, biological activities of therapeutic interest for urgent medical needs, and new molecular targets provides the fuel that sustains the vitality of natural products chemistry research. Unfortunately, finding these important new compounds is neither routine or trivial and a major challenge is finding effective discovery paradigms. This review presents examples that illustrate the effectiveness of a chemical genetics approach to marine natural product (MNP) discovery that intertwines compound discovery, molecular target identification, and phenotypic response/biological activity. The examples include MNPs that have complex unprecedented structures, new or understudied molecular targets, and potent biological activities of therapeutic interest. A variety of methods to identify molecular targets are also featured.

Graphical abstract: Biologically active marine natural products and their molecular targets discovered using a chemical genetics approach

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Publication details

The article was received on 22 Sep 2019 and first published on 21 Nov 2019


Article type: Review Article
DOI: 10.1039/C9NP00054B
Nat. Prod. Rep., 2020, Advance Article

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    Biologically active marine natural products and their molecular targets discovered using a chemical genetics approach

    D. E. Williams and R. J. Andersen, Nat. Prod. Rep., 2020, Advance Article , DOI: 10.1039/C9NP00054B

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