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Recent developments in self-resistance gene directed natural product discovery

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Abstract

Covering: 2000 to 2019

Natural products (NPs) are important sources of human therapeutic agents and pesticides. To prevent self-harm from bioactive NPs, some microbial producers employ self-resistance genes to protect themselves. One effective strategy is to employ a self-resistance enzyme (SRE), which is a slightly mutated version of the original metabolic enzyme, and is resistant to the toxic NP but is still functional. The presence of a SRE in a gene cluster can serve as a predictive window to the biological activity of the NPs synthesized by the pathway. In this highlight, we summarize representative examples of NP biosynthetic pathways that utilize self-resistance genes for protection. Recent discoveries based on self-resistance gene identification have helped in bridging the gap between activity-guided and genome-driven approaches for NP discovery and functional assignment.

Graphical abstract: Recent developments in self-resistance gene directed natural product discovery

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Article information


Submitted
24 Aug 2019
First published
08 Jan 2020

Nat. Prod. Rep., 2020, Advance Article
Article type
Highlight

Recent developments in self-resistance gene directed natural product discovery

Y. Yan, N. Liu and Y. Tang, Nat. Prod. Rep., 2020, Advance Article , DOI: 10.1039/C9NP00050J

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