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Bacterial natural products in the fight against mosquito-transmitted tropical diseases

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Abstract

Covering: up to 2019

Secondary metabolites of microbial origin have long been acknowledged as medically relevant, but their full potential remains largely unexploited. Of the countless natural compounds discovered thus far, only 5–10% have been isolated from microorganisms. At the same time, while whole-genome sequencing has demonstrated that bacteria and fungi often encode natural products, only a few genera have yet been mined for new compounds. This review explores the contributions of bacterial natural products to combatting infection by malaria parasites, filarial worms, and arboviruses such as dengue, Zika, Chikungunya, and West Nile. It highlights how molecules isolated from microorganisms ranging from marine cyanobacteria to mosquito endosymbionts can be exploited as antimicrobials and antivirals. Pursuit of this mostly untapped source of chemical entities will potentially result in new interventions against these tropical diseases, which are urgently needed to combat the increase in the incidence of resistance.

Graphical abstract: Bacterial natural products in the fight against mosquito-transmitted tropical diseases

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Publication details

The article was received on 08 Jul 2019 and first published on 23 Sep 2019


Article type: Review Article
DOI: 10.1039/C9NP00042A
Nat. Prod. Rep., 2020, Advance Article

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    Bacterial natural products in the fight against mosquito-transmitted tropical diseases

    R. G. Saraiva and G. Dimopoulos, Nat. Prod. Rep., 2020, Advance Article , DOI: 10.1039/C9NP00042A

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