Jump to main content
Jump to site search


From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides

Author affiliations

Abstract

Covering: 1989 up to 2019

Ahp-cyclodepsipeptides (also known as Ahp-containing cyclodepsipeptides, cyanopeptolins, micropeptins, microginines, and lyngbyastatins, and by many other names) are a family of non-ribosomal peptide synthesis (NRPS)-derived natural products with potent serine protease inhibitory properties. Here, we review their isolation and structural elucidation from natural sources as well as studies of their biosynthesis, molecular mode of action, and use in drug discovery efforts. Accordingly, this summary aims to provide a comprehensive overview of the current state-of-the-art Ahp-cyclodepsipeptide research.

Graphical abstract: From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 May 2019 and first published on 27 Aug 2019


Article type: Review Article
DOI: 10.1039/C9NP00033J
Nat. Prod. Rep., 2020, Advance Article

  •   Request permissions

    From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides

    S. Köcher, S. Resch, T. Kessenbrock, L. Schrapp, M. Ehrmann and M. Kaiser, Nat. Prod. Rep., 2020, Advance Article , DOI: 10.1039/C9NP00033J

Search articles by author

Spotlight

Advertisements