Issue 46, 2020

One-pot synthesis of 3-hydroxy-2-oxindoles via acyloin rearrangements of 2-hydroxy-indolin-3-ones generated in situ from 2-alkynyl arylazides

Abstract

A novel one-pot method to prepare 3-hydroxy-2-oxindoles via acyloin rearrangements of 2-hydroxy-indolin-3-ones generated in situ from 2-alkynyl arylazides has been described. The reaction was accomplished to afford a variety of 3-hydroxy-2-oxindole derivatives in moderate to good yields under mild conditions.

Graphical abstract: One-pot synthesis of 3-hydroxy-2-oxindoles via acyloin rearrangements of 2-hydroxy-indolin-3-ones generated in situ from 2-alkynyl arylazides

Supplementary files

Article information

Article type
Paper
Submitted
14 Sep 2020
Accepted
09 Nov 2020
First published
09 Nov 2020

New J. Chem., 2020,44, 20303-20307

One-pot synthesis of 3-hydroxy-2-oxindoles via acyloin rearrangements of 2-hydroxy-indolin-3-ones generated in situ from 2-alkynyl arylazides

Z. Zhou, Y. Xu, B. Zhu, P. Li, G. Hu, F. Yang, S. Xu and X. Zhang, New J. Chem., 2020, 44, 20303 DOI: 10.1039/D0NJ04588H

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