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Issue 41, 2020
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Synthesis of 6-substituted indoloquinazolinones from arynes and 2-acyl-4-quinazolinones: a transition-metal free C–N and C–C bond formation strategy

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Abstract

A versatile transition-metal free synthetic strategy has been developed for the direct synthesis of 6-substituted indoloquinazolinones from 2-acyl-4-quinazolinones and aryne precursors under mild conditions. This cascade strategy proceeds via successive C–N and C–C bond formation in a single reaction vessel by simple treatment with CsF and K2CO3. A diverse range of 6-substituted indoloquinazolinones were synthesized in good yields with excellent functional group tolerance.

Graphical abstract: Synthesis of 6-substituted indoloquinazolinones from arynes and 2-acyl-4-quinazolinones: a transition-metal free C–N and C–C bond formation strategy

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Article information


Submitted
02 Sep 2020
Accepted
22 Sep 2020
First published
28 Sep 2020

New J. Chem., 2020,44, 17938-17953
Article type
Paper

Synthesis of 6-substituted indoloquinazolinones from arynes and 2-acyl-4-quinazolinones: a transition-metal free C–N and C–C bond formation strategy

A. Sharma and P. Gogoi, New J. Chem., 2020, 44, 17938
DOI: 10.1039/D0NJ04395H

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