Issue 41, 2020

Synthesis of 6-substituted indoloquinazolinones from arynes and 2-acyl-4-quinazolinones: a transition-metal free C–N and C–C bond formation strategy

Abstract

A versatile transition-metal free synthetic strategy has been developed for the direct synthesis of 6-substituted indoloquinazolinones from 2-acyl-4-quinazolinones and aryne precursors under mild conditions. This cascade strategy proceeds via successive C–N and C–C bond formation in a single reaction vessel by simple treatment with CsF and K2CO3. A diverse range of 6-substituted indoloquinazolinones were synthesized in good yields with excellent functional group tolerance.

Graphical abstract: Synthesis of 6-substituted indoloquinazolinones from arynes and 2-acyl-4-quinazolinones: a transition-metal free C–N and C–C bond formation strategy

Supplementary files

Article information

Article type
Paper
Submitted
02 Sep 2020
Accepted
22 Sep 2020
First published
28 Sep 2020

New J. Chem., 2020,44, 17938-17953

Synthesis of 6-substituted indoloquinazolinones from arynes and 2-acyl-4-quinazolinones: a transition-metal free C–N and C–C bond formation strategy

A. Sharma and P. Gogoi, New J. Chem., 2020, 44, 17938 DOI: 10.1039/D0NJ04395H

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