Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 40, 2020
Previous Article Next Article

Annulations involving 2-arylidene-1,3-indanediones: stereoselective synthesis of spiro- and fused scaffolds

Author affiliations

Abstract

The rapid construction of three dimensional spiro- and fused cyclic skeletons is a challenging goal in synthetic organic chemistry. In this context, readily accessible 2-arylidene-1,3-indanediones meet the demand to a great extent. During the past decades, significant advances have been achieved regarding the annulation of 2-arylidene-1,3-indanediones with suitable reaction partners. This compound could serve as a multiple role player; for example, as a Michael acceptor, dienophile and diene in Diels–Alder reaction, an acceptor in 1,3-dipolar cycloaddition etc. The present review summarizes (since 2012) the stereoselective annulations involving 2-arylidene-1,3-indanediones towards the synthesis of diverse spiro- and fused carbo-/heterocyclic scaffolds based on various cycloadditions and tandem annulation methods. The applications of several important chiral organocatalysts are also highlighted. Most of the reactions described here provide quick access to the desired compounds with impressive stereoselectivity and high atom economy under mild conditions.

Graphical abstract: Annulations involving 2-arylidene-1,3-indanediones: stereoselective synthesis of spiro- and fused scaffolds

Back to tab navigation

Article information


Submitted
07 Aug 2020
Accepted
17 Sep 2020
First published
17 Sep 2020

New J. Chem., 2020,44, 17148-17176
Article type
Perspective

Annulations involving 2-arylidene-1,3-indanediones: stereoselective synthesis of spiro- and fused scaffolds

S. Das, New J. Chem., 2020, 44, 17148
DOI: 10.1039/D0NJ03968C

Social activity

Search articles by author

Spotlight

Advertisements