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Issue 40, 2020
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A novel near-infrared xanthene-based fluorescent probe for detection of thiophenol in vitro and in vivo

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Abstract

Thiophenol (or PhSH) is widely utilized for producing pesticides, dyes, and pharmaceuticals. However, high-concentration thiophenol not only has adverse effects on living organisms, but also causes environment pollution. Herein, we designed and synthesized a novel near-infrared (NIR) xanthene-based fluorescent probe (NOF) for real-time detection of thiophenol in vitro and in vivo. The probe NOF had good sensitivity and selectivity, and a fast response towards thiophenol. The thiophenol-sensing mechanism was verified using high resolution mass spectroscopy (HR-MS) and density functional theory (DFT) calculation. The probe NOF was also successfully applied to detect thiophenol in real water samples. Finally, owing to its NIR-emitting properties, it was successfully used for NIR fluorescence imaging of thiophenol in living cells and mice.

Graphical abstract: A novel near-infrared xanthene-based fluorescent probe for detection of thiophenol in vitro and in vivo

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Supplementary files

Article information


Submitted
05 Jul 2020
Accepted
14 Sep 2020
First published
15 Sep 2020

New J. Chem., 2020,44, 17360-17367
Article type
Paper

A novel near-infrared xanthene-based fluorescent probe for detection of thiophenol in vitro and in vivo

Y. Wu, A. Shi, H. Liu, Y. Li, W. Lun, H. Zeng and X. Fan, New J. Chem., 2020, 44, 17360
DOI: 10.1039/D0NJ03370G

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