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Development of a novel carboxamide-based off–on switch fluorescence sensor: Hg2+, Zn2+ and Cd2+

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Abstract

Here, the carboxamide ligand N-(thiazole-2-yl) picolinamide (L) was synthesized in an ionic liquid tetrabutylammonium bromide (TBAB) as the benign reaction medium. The sensitivity of L towards different metal-ions was investigated, and a comprehensive, logical optical investigation was conducted for the IIB transition metal ions, Hg2+, Cd2+ and Zn2+, based on off–on switch sensor protocols. In the absence of these metal ions, L showed weak emission only, but fluorescence intensity increased considerably upon their addition to a sensitivity range of 10−6 M. This phenomenon was enhanced significantly in the presence of Zn2+ compared to other metal ions, likely due to the coordination of metallic ions to the L, which led to the chelation-enhanced fluorescence (CHEF) effect. To prove these results, several characterization studies were conducted: a single crystal from the metal–ligand complex was prepared, followed by conduction of X-ray single crystal analysis from the Zn-complex (2) and Cd-complex (3), and conducting spectral analysis from the Zn2+, Hg2+ and Cd2+ complexes. These complexes and also the ligand showed very low toxicity on the PC12 cell line suggesting their promise for a wide range of future medical applications.

Graphical abstract: Development of a novel carboxamide-based off–on switch fluorescence sensor: Hg2+, Zn2+ and Cd2+

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Supplementary files

Article information


Submitted
27 May 2020
Accepted
22 Jun 2020
First published
24 Jun 2020

New J. Chem., 2020, Advance Article
Article type
Paper

Development of a novel carboxamide-based off–on switch fluorescence sensor: Hg2+, Zn2+ and Cd2+

M. Kiani, M. Bagherzadeh, S. Meghdadi, N. Rabiee, A. Abbasi, K. Schenk-Joß, M. Tahriri, L. Tayebi and T. J. Webster, New J. Chem., 2020, Advance Article , DOI: 10.1039/D0NJ02595J

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