Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



A mitochondria-targeting ratiometric fluorescent probe for the detection of sulfur dioxide in living cells

Author affiliations

Abstract

Sulfur dioxide (SO2) plays critical biological roles in living systems, and participates in a series of physiological and pathological processes. Aspartate aminotransferase 2 (AAT-2) catalyzes L-cysteine to produce endogenous SO2, which is mainly expressed in the mitochondria of cells. Herein, we present a new mitochondria-targeting and ratiometric fluorescent probe (MNP) for the detection of SO2 in living cells. The probe MNP employed a positively charged benzopyrylium moiety as the response site for SO2, and displayed a selective ratiometric response to SO2 on the basis of a FRET mechanism. Biological experiments demonstrated that the probe MNP was mainly distributed in mitochondria and could be used for the imaging of SO2 in living cells.

Graphical abstract: A mitochondria-targeting ratiometric fluorescent probe for the detection of sulfur dioxide in living cells

Back to tab navigation

Supplementary files

Article information


Submitted
15 May 2020
Accepted
20 Jun 2020
First published
22 Jun 2020

New J. Chem., 2020, Advance Article
Article type
Paper

A mitochondria-targeting ratiometric fluorescent probe for the detection of sulfur dioxide in living cells

Y. Lu, B. Dong, W. Song, Y. Sun, A. H. Mehmood and W. Lin, New J. Chem., 2020, Advance Article , DOI: 10.1039/D0NJ02461A

Social activity

Search articles by author

Spotlight

Advertisements