Fast tyrosinase detection in early stage melanoma with nanomolar sensitivity using a naphthalimide-based fluorescent read-out probe

Abstract

Naphthalimide-based red-emitting fluorescent read-out probes are developed for expeditious and sensitive detection of tyrosinase activity in live-cells. The probes show excellent photostability, pH-tolerance, specificity among several bio-analytes, non-toxicity and extremely fast kinetics for tyrosinase detection with nanomolar sensitivity. The probe is also highly suitable for early melanoma detection.