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Issue 21, 2020
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AgNO3-catalyzed decarboxylative cross-coupling reaction: an approach to coenzyme Q

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Abstract

An efficient and general method for the synthesis of coenzyme Q compounds through the activation of the 1,4-benzoquinone Csp2–H bond has been developed. This C–C bond formation reaction proceeds readily in an open flask by the direct cross-coupling reaction of coenzyme Q0 with commercially available aliphatic carboxylic acids utilizing AgNO3 as a catalyst and K2S2O8 as an oxidant in aqueous solution. This radical reaction is operationally simple and amenable to gram-scale synthesis.

Graphical abstract: AgNO3-catalyzed decarboxylative cross-coupling reaction: an approach to coenzyme Q

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Supplementary files

Article information


Submitted
27 Mar 2020
Accepted
12 May 2020
First published
12 May 2020

New J. Chem., 2020,44, 8702-8704
Article type
Letter

AgNO3-catalyzed decarboxylative cross-coupling reaction: an approach to coenzyme Q

W. Luo, B. Lu, Y. Qiu, R. Zhou, Y. He and J. Wang, New J. Chem., 2020, 44, 8702
DOI: 10.1039/D0NJ01497D

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