Ultrasensitive electroanalytical sulfisoxazole sensors amplified with Pd doped ZnO nanoparticle and 1-hexyl-3-methyl imidazolium bis (tri fluoro methyl sulfonyl) imid modified
In this research, an electrochemical sensor have been introduced through incorporating Pd doped ZnO nanoparticle (ZnO-Pd/NPs) into carbon paste (CP) matrix amplified by a conductive binder (1-hexyl-3-methyl imidazolium bis (trifluoro methylsulfonyl) imid (1H3MIBTMSI), in this case) to determine the concentration of sulfisoxazole (SFX) drug in urine, tablet, and pharmaceutical wastewater samples. ZnO-Pd/NPs nanoparticles were successfully synthesized by a one-pot procedure based on precipitation strategy and characterized by FE-SEM, TEM, EDAX, MAP, and XRD methods. Using ZnO-Pd/NPs/1H3MIBTMSI/CPE as a working electrode, a dramatic increase in the oxidation current of SFX was observed and the sensor was used for determining SFX within the concentration range 0.009 μM to 430 μM (R2=0.9981). Due to high conductivity of ZnO-Pd/NPs/1H3MIBTMSI/CPE, the sensor showed a limit of detection of 5.0 nM and was introduced as the first analytical sensor for determining SFX at the nanomolar level. Real sample analysis results showed a recovery range 98.8-104.15% for determination of SFX that confirm a powerful ability of ZnO-Pd/NPs/1H3MIBTMSI/CPE for determination of SFX in urine and pharmaceutical samples.