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Ruthenocycles of benzothiazolyl and pyridyl hydrazones with ancillary PAHs: synthesis, structure, electrochemistry and antimicrobial activity

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Abstract

Two types of bivalent ruthenium complexes [RuLPy(CO)Cl(PPh3)3] 3 and [RuLBenz(CO)Cl(PPh3)3] 4 were synthesized starting from [RuH(CO)Cl(PPh3)3] and heterocyclic hydrazone ligands 1 and 2 respectively. X-ray diffraction studies reveal that in both types of complexes, the ligands behave as monoanionic bidentate Nhydrazonyl and Npyridyl/Nbenzothiazolyl donors towards ruthenium(II), thereby furnishing four-membered metallacycles. The multiple transitions in the electronic spectra have been elucidated by time dependent density functional theory (TDDFT). The redox active nature of both 3 and 4 has been substantiated from the well-defined oxidative responses and theoretical scrutiny corroborates that one of them is exclusively ligand centred while the other one is chiefly due to the RuII/RuIII oxidation. Both the types of complexes exhibit a significant antimicrobial activity, although the activity of 4 is more prominent, particularly over Pseudomonas. These are analyzed by measuring ZOI, MIC as well as the extent of membrane damage and protein leakage studies. The complexes probably cause free-radical facilitated oxidative damage to the bacterial cells during the course of their activity.

Graphical abstract: Ruthenocycles of benzothiazolyl and pyridyl hydrazones with ancillary PAHs: synthesis, structure, electrochemistry and antimicrobial activity

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Article information


Submitted
24 Mar 2020
Accepted
21 May 2020
First published
03 Jun 2020

New J. Chem., 2020, Advance Article
Article type
Paper

Ruthenocycles of benzothiazolyl and pyridyl hydrazones with ancillary PAHs: synthesis, structure, electrochemistry and antimicrobial activity

S. Dinda, T. Sultana, S. Sultana, S. C. Patra, A. K. Mitra, S. Roy, K. Pramanik and S. Ganguly, New J. Chem., 2020, Advance Article , DOI: 10.1039/D0NJ01447H

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