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Electrospun poly (3-hydroxybutyrate-co-3-hydroxyvalerate) / Polyethylene oxide (PEO) microfibers reinforced with ZnO nanoparticles for antibacterial and antibiofilm wound dressing applications

Abstract

Biocompatible and biodegradable polymers are extensively used in designing wound dressing materials. The present investigation deals with the preparation of a unique blend of zinc oxide (ZnO) nanoparticles incorporated in poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/polyethylene oxide (PEO) microfibers via electrospinning technique for antibacterial, antibiofilm and wound dressing application. This composite was prepared by incorporating previously synthesized ZnO NPs with better antibacterial and antibiofilm activity in PHBV-PEO (4:1) polymers in chloroform solution. Scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR) spectroscopy confirmed that ZnO NPs were incorporated in the PHBV-PEO microfibers. The synthesized microfibers exhibited enhanced mechanical properties after the incorporation of ZnO NPs. The results of antibacterial and antibiofilm activity of the prepared microfibers revealed that the incorporated ZnO NPs in different concentrations (1%, 3%, and 5%) showed different degree of antibacterial activity against pathogenic Gram-positive Staphylococcus aureus (NCIM 2654) and Gram-negative Pseudomonas aeruginosa (NCIM 5032) that are the main culprits in wound infections. The PHBV-PEO-ZnO microfibers exhibited excellent hemocompatibility with improved swelling behavior after the incorporation of ZnO NPs. In vitro cytotoxicity assay revealed the non-toxic nature of the prepared PHBV-PEO- ZnO microfibers. The current work confirms that utilized unique blend of biodegradable, biocompatible, thermoplastic and hydrophobic natural polymer PHBV with hydrophobic, biodegradable, non-toxic and synthetic polymer PEO with ZnO NPs holds great potential to be used as antibacterial and antibiofilm material for wound dressing application.

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Article information


Submitted
19 Mar 2020
Accepted
01 May 2020
First published
07 May 2020

New J. Chem., 2020, Accepted Manuscript
Article type
Paper

Electrospun poly (3-hydroxybutyrate-co-3-hydroxyvalerate) / Polyethylene oxide (PEO) microfibers reinforced with ZnO nanoparticles for antibacterial and antibiofilm wound dressing applications

P. Mahamuni, P. M. Patil, P. Patel, M. J. Dhanavade, M. V. Badiger, Y. Marathe and R. A. Bohara, New J. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0NJ01384F

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