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Polytopic carriers for platinum ions: from digalloyl depside to tannic acid

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Abstract

A novel dinuclear platinum(II) complex, namely [Pt2m-GG(Me2SO-S)4] (8, GG = deprotonated methyl digallate), was easily synthesized under solvent-free conditions by grinding a solid m/p digalloyl depside with the Pt precursor [PtCO3(Me2SO-S)2]. Similarly, platinum nuclei were introduced into the galloyl chains of tannic acid (TA). In particular, three complexes A, B and C were prepared by reacting TA as a polytopic ligand with an increasing amount of [PtCO3(Me2SO-S)2]. The antiproliferative activity of complexes 8, A, B and C together with the corresponding ligands GG and TA was tested in vitro and compared with that of cisplatin on two human tumor cell lines, A2780 (ovarian cisplatin-sensitive) and A2780cis (ovarian cisplatin-resistant), and one non-tumoral cell line, HaCat. The experiments focusing on their pro-apoptotic activity indicated that the antiproliferative activity of the most active Pt(II) complexes is associated with the induction of apoptosis.

Graphical abstract: Polytopic carriers for platinum ions: from digalloyl depside to tannic acid

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Supplementary files

Article information


Submitted
18 Mar 2020
Accepted
22 Jun 2020
First published
22 Jun 2020

New J. Chem., 2020, Advance Article
Article type
Paper

Polytopic carriers for platinum ions: from digalloyl depside to tannic acid

M. Fogagnolo, P. Bergamini, E. Marchesi, L. Marvelli, R. Gambari and I. Lampronti, New J. Chem., 2020, Advance Article , DOI: 10.1039/D0NJ01352H

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