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Polytopic carriers for platinum ions: from digalloyl depside to tannic acid

Abstract

A novel dinuclear platinum(II) complex, [Pt2m-GG(Me2SO-S)4] (8, GG = deprotonated methyl digallate), was easily synthesized under solvent-free conditions by grinding solid m/p digalloyl depside with the Pt precursor [PtCO3(Me2SO-S)2]. Similarly, platinum nuclei have been introduced into the galloyl chains of tannic acid (TA). In particular, three complexes A, B and C were prepared by reaction of TA as polytopic ligand with increasing amounts of [PtCO3(Me2SO-S)2]. The antiproliferative activity of complexes 8, A, B and C along with the corresponding ligands GG and TA was tested in vitro, in comparison with cisplatin, on two human tumor cell lines: A2780 (ovarian cisplatin-sensitive), A2780cis (ovarian cisplatin-resistant) and one non-tumoral cell line HaCat. Experiments focusing on pro-apoptotic activity indicated that the antiproliferative activity of the most active Pt(II) complexes is associated with induction of apoptosis.

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Supplementary files

Article information


Submitted
18 Mar 2020
Accepted
22 Jun 2020
First published
22 Jun 2020

New J. Chem., 2020, Accepted Manuscript
Article type
Paper

Polytopic carriers for platinum ions: from digalloyl depside to tannic acid

P. Bergamini, M. Fogagnolo, E. Marchesi, L. Marvelli, R. Gambari and I. Lampronti, New J. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0NJ01352H

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