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Triazole appending Ruthenium (II) polypyridine complex for selective sensing of phosphate anions through C-H---anion interaction and copper (II) ions via cancer cells

Abstract

A new ruthenium (II) polypyridine based complex [RuII(bpy)2(Btb)] 2PF6- (Rbtb) {bpy = 2,2’-bipyridine and Btb = 2-((1-([2,2’-bipyridin]-4-yl)-1H-1,2,3-triazol-4-yl)methoxy)-1,3-benzothiazole} was constructed using 1,2,3-triazole linker holding benzothiazole moiety. The complex was confirmed by FT-IR, 1H NMR, 13C NMR, and Mass spectrum. For detecting properties, it was thoroughly checked with various anions and cations. The emission spectrum revealed that luminescence gets enhancing by H2PO4-/H2P2O72- anions (2.3/1.9 fold excess) in CH3CN and luminescent quenching (nearly 80%) by Cu2+ ions in CH3CN/10 mM HEPES buffer (pH = 7.4) (9/1, v/v). 1H NMR titration result exhibits basic H2PO4-/H2P2O72- anions interact with acidic triazole C-H is observed from downfield shift. The increase and decrease of lifetime would obey the emission result as disturbance of probe structural motif upon binding with anions (mainly by C-H...anion interaction) and cations (photoinduced electron transfer) respectively. The better detection limit and binding constant values were obtained for Rbtb upon treated with H2PO4-/H2P2O72- anions (0.22/0.31 M and 7.7/4.2 x 104 M-1) and Cu2+ ions (0.7 M and 5.11 x 104 M-1). Noticed, a generation of new separate redox couple at 0.94 V and 0.45 V due to interaction of H2PO4-/H2P2O72- anions and Cu2+ ions respectively. The 1:1 binding ratio of Cu2+ ion with Rbtb was established by mass spectrum and square-based geometry of Rbtb-Cu2+ is classified from EPR spectrum (g÷÷ > g^ > 2.0023 and A÷÷ = 134 x 10-4 cm-1). Consequently, the luminescent intensity of Ru(bpy)3 core is further tuned even the disturbance of acidic C-H proton of 1,2,3-triazole by H2PO4-/H2P2O72- anions. Here, 1,2,3-triazole could not coordinate primarily to ruthenium (II), but bonded directly to the 4th position of 2,2’-bipyridine in the primary ruthenium complex core. However, Rbtb exhibited the low cytotoxicity against MCF-7 cell lines and used to appropriate live-cell imaging of Cu2+ ion. The biological study shows that the complex stained the cytoplasm and nuclei membrane of the cells and exactly binds with metal ion.

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Supplementary files

Article information


Submitted
16 Jan 2020
Accepted
23 Mar 2020
First published
23 Mar 2020

New J. Chem., 2020, Accepted Manuscript
Article type
Paper

Triazole appending Ruthenium (II) polypyridine complex for selective sensing of phosphate anions through C-H---anion interaction and copper (II) ions via cancer cells

R. Mohanraj and S. Anandan, New J. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0NJ00273A

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