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Issue 7, 2020
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Molecular recognition of methamphetamine by carboxylatopillar[5]arene: drug-dependent complexation stoichiometry and insights into medical applications

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Abstract

The molecular recognition of the carboxylatopillar[5]arene on methamphetamine showed interconversion between H2:G [leftrightharpoons] H:G stoichiometries with dependence on drug concentration. The study simulated conditions of severe metabolic acidosis (pH 7.00) and presented intelligent and promising dynamics for the removal of overdosed drugs or poisons in the circulatory system.

Graphical abstract: Molecular recognition of methamphetamine by carboxylatopillar[5]arene: drug-dependent complexation stoichiometry and insights into medical applications

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Article information


Submitted
15 Dec 2019
Accepted
27 Jan 2020
First published
28 Jan 2020

New J. Chem., 2020,44, 2701-2704
Article type
Letter

Molecular recognition of methamphetamine by carboxylatopillar[5]arene: drug-dependent complexation stoichiometry and insights into medical applications

E. V. Silveira, E. H. Wanderlind, A. K. Masson, P. S. Cordeiro, V. Nascimento, R. F. Affeldt and G. A. Micke, New J. Chem., 2020, 44, 2701
DOI: 10.1039/C9NJ06213K

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