Jump to main content
Jump to site search


Synthesis and Antiviral Activity of Novel Myricetin Derivatives Containing a Ferulic Acid Amide Scaffolds

Abstract

A variety of myricetin derivatives bearing ferulic acid amide scaffolds were designed and synthesized. The structures of all title compounds were determined by 1 H NMR, 13 C NMR, 19 F NMR and HRMS. Preliminary bioassays suggested that some of the target compounds exhibited remarkable antiviral activities. In particular, compound 4l possessed significant protective activity against tobacco mosaic virus (TMV), with an half maximal effective concentration (EC50) value of 196.11 μg/mL, which was better than commercial agent ningnamycin (447.92 μg/mL). Meanwhile, microscale thermophoresis (MST) indicated that compound 4l have strong binding capability to tobacco mosaic virus coat protein (TMV-CP) with dissociation constant (Kd) values of 0.34 μmol/L, which was better than ningnamycin (0.52 μmol/L). These results suggested that novel myricetin derivatives bearing ferulic acid amide scaffolds may be considered as an activator for antiviralagents.

Back to tab navigation

Supplementary files

Article information


Submitted
25 Nov 2019
Accepted
09 Jan 2020
First published
10 Jan 2020

New J. Chem., 2020, Accepted Manuscript
Article type
Paper

Synthesis and Antiviral Activity of Novel Myricetin Derivatives Containing a Ferulic Acid Amide Scaffolds

W. Xue, X. Tang, C. Zhang, M. Chen, Y. Xue and T. Liu, New J. Chem., 2020, Accepted Manuscript , DOI: 10.1039/C9NJ05867B

Social activity

Search articles by author

Spotlight

Advertisements