Issue 5, 2020

Anion binding and fluoride ion induced conformational changes in bisurea receptors

Abstract

Two types of bisurea receptors, containing either 2,6-substituted phenyl or 2,6-substituted pyridine, are prepared, and their anion binding properties are investigated. Compared with the phenyl bisurea receptors, the pyridine bisurea receptors can be more easily converted to a ciscis conformation from a transtrans conformation, providing a cavity that more closely matches the volume of a fluoride ion and increasing the number of NH sites bound to the fluoride ion. As a result, the pyridine bisurea in ciscis conformation shows stronger affinity and higher selectivity to fluoride ions, which is supported by crystal structure analysis and NMR titration experiments. Through DFT calculations, a mechanism of fluoride ion induced conformational changes of pyridine bisurea receptors is proposed, and the energy barriers of conformational changes for both types of receptors are determined.

Graphical abstract: Anion binding and fluoride ion induced conformational changes in bisurea receptors

Supplementary files

Article information

Article type
Paper
Submitted
20 Nov 2019
Accepted
13 Jan 2020
First published
14 Jan 2020

New J. Chem., 2020,44, 2033-2045

Anion binding and fluoride ion induced conformational changes in bisurea receptors

X. Shu, Y. Fan, S. Li, Y. Jin, C. Xia and C. Huang, New J. Chem., 2020, 44, 2033 DOI: 10.1039/C9NJ05785D

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