Phenothiazine and amide ornamented novel nitrogen heterocyclic hybrids: Synthesis and their biological and molecular docking studies
Synthesis of novel hybrids, phenothiaze and amide ornamented nitrogen heterocycles 25-34 has been accomplished utilizing multi-step synthetic protocol and the structures have been established based on physical and spectral techniques. Of those, the hybrids possessing meta- nitro (26), para- fluoro (28), meta- and para- methyl (31), ortho- bromo (33) and ortho- and para- dimethyl (34) phenyl carboxamide scaffold exhibited superior anti-inflammatory profile over the standard diclofenac sodium. A hybrid integrated with para- fluorophenyl carboxamide moiety (28) showed the highest DPPH radical scavenging activity among the chemical entities synthesized. Further, the results of anticancer evaluation implied that the hybrid tethered with phenyl carboxamide structural unit (29) exerted superior activity when compared with other hybrids against the pancreatic cancer cells SW1990 and AsPCl. Molecular docking between the hybrid 29 and B-cell lymphoma 2 reflects its appreciable binding affinity (-8.84 Kcal / mol). The results revealed that these chemical entities could serve as potent biological agents and / or serve as efficient intermediates for the construction of potent biological agents.