Jump to main content
Jump to site search


Peroxynitrite (ONOO) generation from the HA-TPP@NORM nanoparticles based on synergistic interactions between nitric oxide and photodynamic therapies for elevating anticancer efficiency

Author affiliations

Abstract

Due to biological safety and negligible toxicity, nitric oxide (NO) therapy has gained increasing interest in the field of cancer therapy during the past few years. However, individual NO cancer therapy normally exhibited limited therapeutic efficiency. In order to acquire satisfactory therapeutic outcomes, the NO therapy is usually combined with other therapeutic treatments, mostly chemotherapy. Herein, we constructed HA-TPP@NORM nanoparticles based on the co-assembly of an NO donor (NORM) and tetraphenylporphyrin (TPP)-modified hyaluronic acid, which can efficiently generate a highly biocidal molecule of peroxynitrite (ONOO) via the synergistic interactions of the nitric oxide (NO) therapy and photodynamic therapy (PDT) to enhance the cancer therapeutic efficiency. In addition, MTT results exhibited that without light irradiation, the HA-TPP@NORM nanoparticles have favourable biocompatibility with the cell viability above 95% at the maximum TPP concentration (20 μg mL−1). Under simultaneous irradiation with 365 nm and 650 nm light, ONOO can be efficiently produced in cancer cells via the direct coupling reaction of the generated NO and superoxide anion radical (O2˙), which significantly enhanced the anticancer effect, when compared with individual NO therapy or PDT therapy. Therefore, the HA-TPP@NORM nanoparticles may provide a new insight into the design of efficiently NO-related cancer therapeutic systems.

Graphical abstract: Peroxynitrite (ONOO−) generation from the HA-TPP@NORM nanoparticles based on synergistic interactions between nitric oxide and photodynamic therapies for elevating anticancer efficiency

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 Sep 2019, accepted on 19 Nov 2019 and first published on 19 Nov 2019


Article type: Paper
DOI: 10.1039/C9NJ04763H
New J. Chem., 2020, Advance Article

  •   Request permissions

    Peroxynitrite (ONOO) generation from the HA-TPP@NORM nanoparticles based on synergistic interactions between nitric oxide and photodynamic therapies for elevating anticancer efficiency

    D. Jiang, T. Yue, G. Wang, C. Wang, C. Chen, H. Cao and Y. Gao, New J. Chem., 2020, Advance Article , DOI: 10.1039/C9NJ04763H

Search articles by author

Spotlight

Advertisements