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Anti-pseudo-allergic capacity of alkaloids screened from Uncaria rhynchophylla

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Abstract

Uncaria rhynchophylla (UR) is a traditional Chinese herb widely used for hyperpyrexia, epilepsy, preeclampsia, and hypertension. In this paper, the potential anti-pseudo-allergic components in UR were explored. Six alkaloids in UR possessed good retention properties on an established MRGPRX2/CMC model. Among them, isorhynchophylline (Isorhy) and corynoxeine (Cor) could inhibit the pseudo-allergic reaction induced by C48/80 both in vivo and in vitro. Therefore, this study provides evidence for the anti-pseudo-allergic effect of UR and for development of the biological activity of this genus.

Graphical abstract: Anti-pseudo-allergic capacity of alkaloids screened from Uncaria rhynchophylla

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Publication details

The article was received on 03 Sep 2019, accepted on 19 Nov 2019 and first published on 20 Nov 2019


Article type: Paper
DOI: 10.1039/C9NJ04551A
New J. Chem., 2020, Advance Article

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    Anti-pseudo-allergic capacity of alkaloids screened from Uncaria rhynchophylla

    Y. Xie, D. Wei, T. Hu, Y. Hou, Y. Lin, H. He and C. Wang, New J. Chem., 2020, Advance Article , DOI: 10.1039/C9NJ04551A

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