Jump to main content
Jump to site search

Issue 14, 2020
Previous Article Next Article

Cu(ii) salen and 1,2,4-triazole complexes from thiosemicarbazone: synthesis, physicochemical and structural properties and cytotoxic activities

Author affiliations

Abstract

A triazole complex of copper(II) containing ethylenediamine as a coligand was synthesized using salicylaldehydethiosemicarbazone in the presence of CuCl2. Also, a dinuclear copper(II) complex was synthesized using the same reagents; however, the order of their addition was different. The structures of these two complexes were characterized via elemental analysis, IR, 1H-NMR, and UV-Vis spectroscopy and mass spectrometry (MS). Furthermore, the molecular structures of complexes I and II were determined via single-crystal X-ray structure analysis. The copper(II) ion has a distorted square-pyramidal geometry in complex I and a distorted square-planar geometry in complex II. Their fragmentation products were investigated in detail by ESI-MS. Finally, the cytotoxic effects of both complexes were evaluated in MDA-MB-231, MCF-7 and 3T3 fibroblast cell lines via the MTT assay and flow cytometry.

Graphical abstract: Cu(ii) salen and 1,2,4-triazole complexes from thiosemicarbazone: synthesis, physicochemical and structural properties and cytotoxic activities

Back to tab navigation

Supplementary files

Article information


Submitted
29 Aug 2019
Accepted
06 Mar 2020
First published
10 Mar 2020

New J. Chem., 2020,44, 5333-5342
Article type
Paper

Cu(II) salen and 1,2,4-triazole complexes from thiosemicarbazone: synthesis, physicochemical and structural properties and cytotoxic activities

E. Avcu Altiparmak, G. Erdemir, N. Özdemir, S. E. Kuruca and T. Bal-Demirci, New J. Chem., 2020, 44, 5333
DOI: 10.1039/C9NJ04455H

Social activity

Search articles by author

Spotlight

Advertisements