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Biomimetic hybrid membrane-based nanoplatforms: synthesis, properties and biomedical applications

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Abstract

The rapid clearance and capture by the immune system pose a big challenge in targeted drug delivery using nanocarriers. Cell membrane coating endows nanoplatforms with prolonged blood circulation, enhanced immune escape, and improved targeting capability. However, monotypic cell membrane fails to meet the omnifarious needs of biomedical applications. The combination of different types of cell membranes provides a promising solution to provide multifunctional biomimetic nanoplatforms. In this review, we first discuss the feasibility of constructing biomimetic hybrid membranes and summarize current methods of preparing biomimetic hybrid membrane-based nanoplatforms (BHMNs) and their biomedical applications including drug delivery, cancer detection, detoxification, and cancer vaccines. Finally, the prospects and challenges of utilizing BHMNs for personalized medicine are also discussed.

Graphical abstract: Biomimetic hybrid membrane-based nanoplatforms: synthesis, properties and biomedical applications

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Article information


Submitted
06 May 2020
Accepted
22 Jun 2020
First published
22 Jun 2020

Nanoscale Horiz., 2020, Advance Article
Article type
Minireview

Biomimetic hybrid membrane-based nanoplatforms: synthesis, properties and biomedical applications

Y. Liao, Y. Zhang, N. T. Blum, J. Lin and P. Huang, Nanoscale Horiz., 2020, Advance Article , DOI: 10.1039/D0NH00267D

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