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Sound-driven dissipative self-assembly of aromatic biomolecules into functional nanoparticles

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Abstract

Dissipative self-assembly processes were recently exploited to assemble synthetic materials into supramolecular structures. In most cases, chemical fuel or light driven self-assembly of synthetic molecules was reported. Herein, experimental and computational approaches were used to unveil the role of acoustic cavitation in the formation of supramolecular nanoaggregates by dissipative self-assembly. Acoustic cavitation bubbles were employed as an energy source and a transient interface to fuel and refuel the dissipative self-assembly of simple aromatic biomolecules into uniform nanoparticles. Molecular dynamics simulations were applied to predict the formation of metastable aggregates and the dynamic exchange of the interacting molecules in the nanoaggregates. The intracellular trafficking and dissipative dissolution of the nanoparticles were tracked by microscopy imaging.

Graphical abstract: Sound-driven dissipative self-assembly of aromatic biomolecules into functional nanoparticles

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Article information


Submitted
18 Sep 2019
Accepted
11 Dec 2019
First published
11 Dec 2019

Nanoscale Horiz., 2020, Advance Article
Article type
Communication

Sound-driven dissipative self-assembly of aromatic biomolecules into functional nanoparticles

S. K. Bhangu, G. Bocchinfuso, M. Ashokkumar and F. Cavalieri, Nanoscale Horiz., 2020, Advance Article , DOI: 10.1039/C9NH00611G

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