Jump to main content
Jump to site search


Remote-controlled multi-enzyme system for enhanced tumor therapy via dark/light relay catalysis

Author affiliations

Abstract

Nanozymes have been widely used in biomedicine, especially in tumor therapy. However, inadequate H2O2 supply in the tumor microenvironment (TME) and uncontrolled catalytic activity of nanozymes in vivo restrict their practical application. Here, a dark/light relay strategy is proposed to realize adequate H2O2 supply in the dark reaction stage and selectively perform desired catalytic activities for toxic reactive oxygen species (ROS) generation to kill tumors by remote light control. A tumor membrane camouflaged and glucose oxidase (GOx) loaded hollow mesoporous Prussian blue (mGPB) nanosystem is designed to target tumor tissues for homologous aggregation of membranes. The cascaded catalysis of superoxide dismutase (SOD) and catalase (CAT)-like activities inherited from hollow mesoporous Prussian blue (HMPB) efficiently catalyze endogenous O2˙ to O2, which contributes to the oxidative decomposition of glucose to produce H2O2 by loaded GOx. Moreover, mGPB nanoparticles are found to utilize H2O2 to produce ˙OH and 1O2 under NIR irradiation via other light-dependent dual-catalytic properties, acting as peroxidase (POD) and oxidase (OXD). By dark/light relay catalysis, we successfully overcome the limited H2O2 supply in TME and achieve precise ROS generation, displaying prominent tumor suppression in mouse xenograft models.

Graphical abstract: Remote-controlled multi-enzyme system for enhanced tumor therapy via dark/light relay catalysis

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Sep 2019, accepted on 11 Oct 2019 and first published on 11 Oct 2019


Article type: Communication
DOI: 10.1039/C9NH00583H
Nanoscale Horiz., 2020, Advance Article

  •   Request permissions

    Remote-controlled multi-enzyme system for enhanced tumor therapy via dark/light relay catalysis

    Y. Chen, Z. Li, J. Hu, S. Peng, L. Rong, Y. Sun and X. Zhang, Nanoscale Horiz., 2020, Advance Article , DOI: 10.1039/C9NH00583H

Search articles by author

Spotlight

Advertisements