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A soft X-ray activated lanthanide scintillator for controllable NO release and gas-sensitized cancer therapy

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Abstract

Multifunctional light stimuli-responsive NO-based gaseous theranostic systems are highly desirable due to them directly killing cancer cells at high concentration (>1 μM) with minimized adverse effects. However, on-demand NO-releasing nano-platforms for deep-tissue gas-based cancer therapy have not yet been explored. Herein, we develop a new type of soft X-ray-activated NaYF4:Gd/Tb scintillator as a light transducer for depth-independent NO release and on-demand gas-sensitized cancer therapy. Benefiting from the excellent radioluminescent property of NaYF4:Gd/Tb, deep-tissue (up to 3 cm) NO release can be achieved by ultralow dosage soft X-ray (45 kVp, 0.18–0.85 mGy) irradiation. More importantly, the designed scintillator-based NO gasotransmitter presents significant inhibition of tumor growth under ultralow dosage soft X-ray irradiation. Therefore, such a soft X-ray activated NO-releasing nanoplatform provides a promising depth-independent gaseous therapy mode for defeating deep-seated cancer in the future.

Graphical abstract: A soft X-ray activated lanthanide scintillator for controllable NO release and gas-sensitized cancer therapy

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Publication details

The article was received on 26 Aug 2019, accepted on 09 Sep 2019 and first published on 09 Sep 2019


Article type: Communication
DOI: 10.1039/C9NH00564A
Nanoscale Horiz., 2020, Advance Article

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    A soft X-ray activated lanthanide scintillator for controllable NO release and gas-sensitized cancer therapy

    M. Jiang, Z. Xue, Y. Li, H. Liu, S. Zeng and J. Hao, Nanoscale Horiz., 2020, Advance Article , DOI: 10.1039/C9NH00564A

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