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Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts

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Abstract

Macrophages can be polarized to M1 or M2 type with pro-inflammatory or anti-inflammatory properties. Nanoparticles have recently been found to be a promising platform to polarize macrophages to desired phenotypes. This article explores the usage of cell membrane-derived nanoparticles (nanoghosts) for reprogramming macrophages. The efficacy and efficiency of this technology are examined via cytokine analysis and immunostaining of the nanoghost-treated cells. We find that several cytokines/chemokines are highly expressed on nanoghosts. In addition, a 2D wound healing model is deployed to reveal their potential application in clinical settings.

Graphical abstract: Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts

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Article information


Submitted
13 Jul 2020
Accepted
09 Sep 2020
First published
09 Sep 2020

This article is Open Access

Nanoscale Adv., 2020, Advance Article
Article type
Paper

Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts

J. Hwang, M. Zheng, C. Wiraja, M. Cui, L. Yang and C. Xu, Nanoscale Adv., 2020, Advance Article , DOI: 10.1039/D0NA00572J

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