Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Nanoscale laser-induced breakdown spectroscopy imaging reveals chemical distribution with subcellular resolution

Abstract

Understanding chemical compositions is one of the most important parts in exploring the micro world. As a simple method for elemental detection, laser-induced breakdown spectroscopy (LIBS) is widely used in material, geological and life science fields. However, due to the long-existing limitation in spatial resolution, LIBS is difficult to play an analytical role in the field of low microns or even nanometers. Herein, we firstly report a reliable nanoscale resolution LIBS imaging technique by introducing the sampling laser with a micro-lensed fiber. Through the emission enhancement by double-pulse laser, we obtained the spectral signal from a sampling crater of less than 500 nanometers in diameter, and visualized the chemical distribution of the self-made grid sample, SIM chip and nano-particles in single cells. The relative limits of detection (RLOD) of In and absolute limits of detection (ALOD) of Al can reach 0.6% and 18.3 fg, respectively.

Back to tab navigation

Article information


Submitted
10 May 2020
Accepted
27 Jun 2020
First published
29 Jun 2020

This article is Open Access

Nanoscale Adv., 2020, Accepted Manuscript
Article type
Paper

Nanoscale laser-induced breakdown spectroscopy imaging reveals chemical distribution with subcellular resolution

Y. Meng, C. Gao, Z. Lin, W. Hang and B. Huang, Nanoscale Adv., 2020, Accepted Manuscript , DOI: 10.1039/D0NA00380H

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements