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2D AuPd alloy nanosheets: one-step synthesis as imaging-guided photonic nano-antibiotics

Abstract

The complicated synthesis and undesirable biocompatibility of nanomaterials hinder the synergistic photothermal/photodynamic therapy for bacterial infections. Herein, we develop a one-step preparation of 2D AuPd alloy nanosheets as imaging-guided photonic nano-antibiotics. 2D AuPd alloy nanosheets with an extremely small thickness (~1.5 nm) exhibit prominent photothermal effects (η=76.6%), excellent ROS generation, strong photoacoustic signals as well as desirable biocompatibility. AuPd nanosheets can eliminate 100% of representative Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli) when irradiated by 808 nm laser at 1 W/cm2 for 5 minutes. After modified with bacterial targeting peptide, under the guidance of photoacoustic imaging, AuPd nanosheets achieve promising synergetic photothermal/photodynamic therapeutic efficacy on treating Staphylococcus aureus infected mice. This work expands the biomedical application of 2D noble metal nanomaterials to the field of photonic nano-antibiotics.

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Supplementary files

Article information


Submitted
30 Apr 2020
Accepted
25 Jun 2020
First published
26 Jun 2020

This article is Open Access

Nanoscale Adv., 2020, Accepted Manuscript
Article type
Paper

2D AuPd alloy nanosheets: one-step synthesis as imaging-guided photonic nano-antibiotics

S. He, G. Zhu, Z. Sun, J. Wang, P. Hui, P. Zhao, W. Chen and X. Jiang, Nanoscale Adv., 2020, Accepted Manuscript , DOI: 10.1039/D0NA00342E

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