2D AuPd alloy nanosheets: one-step synthesis as imaging-guided photonic nano-antibiotics
The complicated synthesis and undesirable biocompatibility of nanomaterials hinder the synergistic photothermal/photodynamic therapy for bacterial infections. Herein, we develop a one-step preparation of 2D AuPd alloy nanosheets as imaging-guided photonic nano-antibiotics. 2D AuPd alloy nanosheets with an extremely small thickness (~1.5 nm) exhibit prominent photothermal effects (η=76.6%), excellent ROS generation, strong photoacoustic signals as well as desirable biocompatibility. AuPd nanosheets can eliminate 100% of representative Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli) when irradiated by 808 nm laser at 1 W/cm2 for 5 minutes. After modified with bacterial targeting peptide, under the guidance of photoacoustic imaging, AuPd nanosheets achieve promising synergetic photothermal/photodynamic therapeutic efficacy on treating Staphylococcus aureus infected mice. This work expands the biomedical application of 2D noble metal nanomaterials to the field of photonic nano-antibiotics.