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Fluorous Biphase Drug Delivery System Triggered by Low Frequency Ultrasound: Controlled Release from Perfluorous Discoidal Porous Silicon Particles

Abstract

Conventional drug delivery systems face unsatisfactory loading efficiency, poor biological bypass, and uncontrollable release, which are great barriers for improving the treatment of many diseases. Herein, a proof-of-concept of a fluorous biphase drug delivery system (FB-DDS) trigged by low frequency ultrasound (LFUS) was proposed for the first time, where promoted incorporating and stabilizing theraputic agents in the nanocarriers was achieved through fluorine-fluorine interactions, and the encapsulated drugs were controllably released by external sources, resulting of minimized nonspecific toxicity and enhanced therapeutic efficacy. The FB-DDS was constructed from monodisperse, discoidal porous silicon particles (PSP) and was functionalized with 1H,1H,2H,2H-perfluorodecyltrimethoxysilane (FAS17) for loading perfluoropentane (PFP) and fluorinated drugs through the fluorine-fluorine interactions. This delivery system was demonstrated by utilizing model compounds including fluorous-tagged fluorescein and fluorine containing antibiotic ciprofloxacin. Loading of the model molecules into fluorocarbon-coated carriers was facilitated by the fluorous interactions, whereas ejection of the model molecules was promoted by applying LFUS to rapidly evaporate PFP. In the in vitro test, these carriers loaded with fluorine containing ciprofloxacin exhibited excellent antimicrobial activity against Pseudomonas aeruginosa biofilm formation. Overall, this innovative stimuli-responsive fluorous biphase drug delivery system will be a promising candidate for practical applications as well as encouraging further investigation in drug delivery and controlled release strategies.

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Supplementary files

Article information


Submitted
24 Apr 2020
Accepted
25 Jun 2020
First published
30 Jun 2020

This article is Open Access

Nanoscale Adv., 2020, Accepted Manuscript
Article type
Paper

Fluorous Biphase Drug Delivery System Triggered by Low Frequency Ultrasound: Controlled Release from Perfluorous Discoidal Porous Silicon Particles

J. Liu, S. Li, L. Liu and Z. Zhu, Nanoscale Adv., 2020, Accepted Manuscript , DOI: 10.1039/D0NA00324G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

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